4-Hydroxymethyl-5-methylimidazole
- CAS: 29636-87-1
- Purity: 99%
- China cas 29636-87-1 manufacturer wholesale 4-Hydroxymethyl-5-methylimidazole at affordable price
China cas 29636-87-1 manufacturer wholesale 4-Hydroxymethyl-5-methylimidazole at affordable price
- Molecular Formula: C5H8 N2 O
- Molecular Weight: 112.131
- Appearance/Colour: White and light brown Crystalsl Powder
- Vapor Pressure: 9.46E-07mmHg at 25°C
- Melting Point: 136°C
- Refractive Index: 1.574
- Boiling Point: 389.1 °C at 760 mmHg
- PKA: 13.62±0.10(Predicted)
- Flash Point: 189.1 °C
- PSA: 48.91000
- Density: 1.231 g/cm3
- LogP: 0.21040
4-Hydroxymethyl-5-methylimidazole(Cas 29636-87-1) Usage
|
General Description |
4-Hydroxymethyl-5-methylimidazole is a chemical compound mainly known for its role in the formation of certain types of vitamins, particularly Vitamin B1 or thiamine. It is used in synthetic processes in the pharmaceutical industry due to its imidazole ring, a common structure found in many biologically active molecules. Despite being less studied compared to other imidazole derivatives, it is instrumental in the synthesis of vitamin B1 analogs and optically active α-methyl amino acids. Regarding its safety, there isn't extensive information available, however, like any chemical substance, proper handling and appropriate safety measures should be followed while using it. |
InChI:InChI=1/C5H8N2O/c1-4-5(2-8)7-3-6-4/h3,8H,2H2,1H3,(H,6,7)
29636-87-1 Relevant articles
Homo- and Heterodinuclear Ir and Rh Imine-functionalized Protic NHC Complexes: Synthetic, Structural Studies, and Tautomerization/Metallotropism Insights
He, Fan,Wesolek, Marcel,Danopoulos, Andreas A.,Braunstein, Pierre
, p. 2658 - 2671 (2016)
The influence of the potentially chelati...
Synthesis of some histidine analogs and their effect on the growth of a histidine-requiring mutant of Leuconostoc mesenteroides.
Trout
, p. 1259 - 1261 (1972)
-
Highly potent geminal bisphosphonates. From pamidronate disodium (Aredia) to zoledronic acid (Zometa)
Widler, Leo,Jaeggi, Knut A.,Glatt, Markus,Müller, Klaus,Bachmann, Rolf,Bisping, Michael,Born, Anne-Ruth,Cortesi, Reto,Guiglia, Gabriela,Jeker, Heidi,Klein, Rémy,Ramseier, Ueli,Schmid, Johann,Schreiber, Gerard,Seltenmeyer, Yves,Green, Jonathan R.
, p. 3721 - 3738 (2007/10/03)
Bisphosphonates (BPs) are pyrophosphate ...
Imidazole-containing inhibitors of farnesyl protein transferase
-
, (2008/06/13)
Inhibition of farnesyl transferase, whic...
Substituted 1H-imidazoles
-
, (2008/06/13)
New substituted 1H-imidazoles and their ...
29636-87-1 Process route
-
-
5-methylimidazole-4-carboxylic acid sodium salt
-
-
29636-87-1
4(5) -methyl-5(4) -hydroxymethylimidazole
| Conditions | Yield |
|---|---|
|
With
sodium hydroxide; formaldehyd;
In
water;
|
65%
|
-
-
51605-32-4
Ethyl 5-Methyl-4-imidazolecarboxylate
-
-
29636-87-1
4(5) -methyl-5(4) -hydroxymethylimidazole
| Conditions | Yield |
|---|---|
|
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 ℃;
for 4h;
Reflux;
|
89%
|
|
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
for 4h;
Heating;
|
55%
|
29636-87-1 Upstream products
-
50-00-0
formaldehyd
-
822-36-6
4-methyl-1H-imidazole
-
51605-32-4
ethyl 4(5) -methylimidazole-5(4) -carboxylate
-
73166-01-5
(4-methyl-imidazol-1-yl)-methanol
29636-87-1 Downstream products
-
2302-39-8
4,5-dimethylimidazole
-
1457-59-6
4(5) -methylimidazole-5(4) -carboxylic acid
-
1234388-36-3
C23 H22 N2 OSi
-
106147-84-6
4-Hydroxymethyl-5-methyl-1-(triphenylmethyl)imidazole