1-benzylpiperidine-4-acetonitrile
- CAS: 78056-67-4
- Purity: 99%
- Manufacturer supply good quality 1-benzylpiperidine-4-acetonitrile 78056-67-4 with stock
Manufacturer supply good quality 1-benzylpiperidine-4-acetonitrile 78056-67-4 with stock
- Molecular Formula: C14H18 N2
- Molecular Weight: 214.31
- Vapor Pressure: 4.88E-05mmHg at 25°C
- Boiling Point: 348.9°C at 760 mmHg
- Flash Point: 147.4°C
- PSA： 27.03000
- Density: 1.036g/cm3
- LogP: 2.75018
1-benzylpiperidine-4-acetonitrile(Cas 78056-67-4) Usage
|
General Description |
1-benzylpiperidine-4-acetonitrile is a chemical compound with the molecular formula C17H21N. It is a derivative of piperidine and is used as an intermediate in the synthesis of various pharmaceuticals and organic compounds. 1-benzylpiperidine-4-acetonitrile is a white to off-white solid at room temperature and is sparingly soluble in water. It is commonly used in the pharmaceutical industry as a building block for the synthesis of various drugs, including antipsychotic and analgesic medications. Additionally, 1-benzylpiperidine-4-acetonitrile is also used as a reagent in organic synthesis and as a precursor for the formation of heterocycles. |
InChI:InChI=1/C14H18N2/c15-9-6-13-7-10-16(11-8-13)12-14-4-2-1-3-5-14/h1-5,13H,6-8,10-12H2
78056-67-4 Relevant articles
Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation
Wu, Ming-Yu,Esteban, Gerard,Brogi, Simone,Shionoya, Masahi,Wang, Li,Campiani, Giuseppe,Unzeta, Mercedes,Inokuchi, Tsutomu,Butini, Stefania,Marco-Contelles, Jose
, p. 864 - 879 (2016/08/18)
Currently available drugs against Alzhei...
Multi-target-oriented protective agent neurocyte
-
Paragraph 0118; 0119; 0122, (2017/03/28)
PROBLEM TO BE SOLVED: To provide a promi...
Neuroprotective multi-target directed drugs
-
Paragraph 0100; 0103, (2014/05/20)
A new family of multitarget molecules ab...
Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease
Wang, Li,Esteban, Gerard,Ojima, Masaki,Bautista-Aguilera, Oscar M.,Inokuchi, Tsutomu,Moraleda, Ignacio,Iriepa, Isabel,Samadi, Abdelouahid,Youdim, Moussa B.H.,Romero, Alejandro,Soriano, Elena,Herrero, Raquel,Fernández Fernández, Ana Patricia,Ricardo-Martínez-Murillo,Marco-Contelles, José,Unzeta, Mercedes
, p. 543 - 561 (2014/06/09)
The synthesis, biochemical evaluation, A...
78056-67-4 Process route
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55022-82-7
2-(1-benzylpiperidin-4-ylidene)acetonitrile
-
-
78056-67-4
1-(phenylmethyl)-4-piperidineacetonitrile
| Conditions | Yield |
|---|---|
|
2-(1-benzylpiperidin-4-ylidene)acetonitrile;
With
magnesium;
In
methanol;
at 5 - 10 ℃;
for 4h;
With
hydrogenchloride;
In
methanol; water;
With
sodium hydroxide;
In
methanol; water;
|
82%
|
|
With
magnesium;
In
methanol;
for 4h;
Ambient temperature;
|
74%
|
|
With
methanol; magnesium;
|
|
|
With
platinum on activated charcoal; hydrogen;
at 20 ℃;
for 10h;
under 15514.9 Torr;
|
|
|
2-(1-benzylpiperidin-4-ylidene)acetonitrile;
With
iodine; magnesium;
In
methanol;
With
hydrogenchloride;
In
methanol; water;
|
1.59 g
|
|
With
iodine; magnesium;
In
methanol;
|
1.59 g
|
|
With
iodine; magnesium;
In
methanol;
at 0 - 20 ℃;
|
|
|
With
iodine; magnesium;
In
methanol;
|
1.59 g
|
-
-
ethyl α-cyano-1-(phenylmethyl)-4-piperidineacetate
-
-
78056-67-4
1-(phenylmethyl)-4-piperidineacetonitrile
| Conditions | Yield |
|---|---|
|
With
sodium hydroxide;
In
N,N-dimethyl acetamide; water;
|
35 parts (82%)
|
78056-67-4 Upstream products
-
55022-82-7
2-(1-benzylpiperidin-4-ylidene)acetonitrile
-
3612-20-2
1-phenylmethyl-4-piperidone
-
743417-80-3
methyl N-benzyl-piperidin-4-yl-cyanoacetate
-
616897-44-0
2-(1-benzylpiperidin-4-ylidene)malononitrile
78056-67-4 Downstream products
-
120014-32-6
(1-benzylpiperidin-4-yl)acetaldehyde
-
130927-83-2
2-(1-benzylpiperidin-4-yl)acetic acid
-
757236-89-8
2-amino-N -[2-(1-benzyl-piperidin-4-yl)-ethyl]-acetamide
-
757236-88-7
{[2-(1-benzyl-piperidin-4-yl)-ethylcarbamoyl]-methyl}-carbamic acid tert -butyl ester
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