Tetrahydro-2-methyl-3-thioxo-1,2,4-triazine-5,6-dione
- CAS: 58909-39-0
- Purity: 99%
- Excellent chemical plant bulk supply Tetrahydro-2-methyl-3-thioxo-1,2,4-triazine-5,6-dione 58909-39-0
Excellent chemical plant bulk supply Tetrahydro-2-methyl-3-thioxo-1,2,4-triazine-5,6-dione 58909-39-0
- Molecular Formula: C4H5N3O2S
- Molecular Weight: 159.169
- Appearance/Colour: white powder
- Vapor Pressure: 0.000795mmHg at 25°C
- Melting Point: 168-171 °C(lit.)
- Refractive Index: 1.678
- Boiling Point: 272.3 °C at 760 mmHg
- PKA: 5.34±0.20(Predicted)
- Flash Point: 118.5 °C
- PSA： 102.74000
- Density: 1.62 g/cm3
- LogP: -0.86880
Tetrahydro-2-methyl-3-thioxo-1,2,4-triazine-5,6-dione(Cas 58909-39-0) Usage
|
General Description |
Tetrahydro-2-methyl-3-thioxo-1,2,4-triazine-5,6-dione is an intermediate for synthesizing ceftriaxone. |
InChI:InChI=1/C4H5N3O2S/c1-7-4(10)5-2(8)3(9)6-7/h1H3,(H,6,9)(H,5,8,10)
58909-39-0 Relevant articles
Preparation method of triazine ring
-
Paragraph 0017; 0035-0050, (2021/05/08)
The invention belongs to the technical f...
Tricyclic synthesis process of triazine
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Paragraph 0024-0031, (2019/04/06)
The invention discloses a tricyclic synt...
The use of mixed solvent to synthesize triazine ring new method
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Paragraph 0022; 0023; 0024; 0025; 0026; 0027; 0028-0031, (2017/10/07)
The invention relates to a novel method ...
HPLC and 1H-NMR studies of alkaline hydrolysis of some 7-(oxyiminoacyl)cephalosporins
Vilanova,Munoz,Donoso,Garcia Blanco
, p. 2789 - 2802 (2007/10/02)
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58909-39-0 Process route
-
-
6938-68-7
2-methyl-thiosemicarbazide
-
-
95-92-1
oxalic acid diethyl ester
-
-
58909-39-0
2-methyl-3-mercapto-5-oxo-6-hydroxy-2,5-dihydro-1,2,4-triazine
| Conditions | Yield |
|---|---|
|
With
dmap; N,N,N,N,-tetramethylethylenediamine; sodium methylate;
In
methanol; ethanol;
at 15 - 55 ℃;
for 4h;
Temperature;
Solvent;
Reagent/catalyst;
|
92.7%
|
|
With
sodium methylate;
In
methanol; dimethyl sulfoxide;
at 0 - 45 ℃;
Solvent;
|
91.6%
|
-
-
553-90-2
Dimethyl oxalate
-
-
ammonium thiocyanate
-
-
60-34-4
methylhydrazine
-
-
58909-39-0
2-methyl-3-mercapto-5-oxo-6-hydroxy-2,5-dihydro-1,2,4-triazine
| Conditions | Yield |
|---|---|
|
ammonium thiocyanate; methylhydrazine;
In
water;
at 95 - 100 ℃;
Dimethyl oxalate;
With
sodium methylate;
In
methanol;
at 65 - 75 ℃;
for 6h;
Temperature;
|
75%
|
58909-39-0 Upstream products
-
6938-68-7
2-methyl-thiosemicarbazide
-
95-92-1
oxalic acid diethyl ester
-
553-90-2
Dimethyl oxalate
-
60-34-4
methylhydrazine
58909-39-0 Downstream products
-
119742-06-2
L-659,286
-
73384-59-5
ceftriaxone
-
58909-56-1
7-aminoceftrizine
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58909-56-1
7-amino-3-[(2,5-dihydro-6-hydroxy-2-methyl-5-oxo-1,2,4-triazine-3-mercapto)methyl]-3 cephalosporin-4-carboxylic acid
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