Ethyl 1-methylnipecotate
- CAS: 5166-67-6
- Purity: 99%
- Manufacturer supply good quality Ethyl 1-methylnipecotate 5166-67-6 with stock
Manufacturer supply good quality Ethyl 1-methylnipecotate 5166-67-6 with stock
- Molecular Formula: C9H17NO2
- Molecular Weight: 171.239
- Appearance/Colour: Clear colorless to pale yellow liquid
- Vapor Pressure: 0.186mmHg at 25°C
- Refractive Index: n20/D 1.451(lit.)
- Boiling Point: 211.1 °C at 760 mmHg
- PKA: 8.56±0.10(Predicted)
- Flash Point: 68.3 °C
- PSA： 29.54000
- Density: 0.997 g/cm3
- LogP: 0.82920
Ethyl 1-methylnipecotate(Cas 5166-67-6) Usage
|
General Description |
Enantiomeric discrimination has been investigated in 1H and 13C NMR spectra of ethyl 1-methyl-3-piperidinecarboxylate in the presence of (-)-(18-crown-6)-2,3,11,12-tetracarboxylic acid. |
InChI:InChI=1/C9H17NO2/c1-3-12-9(11)8-5-4-6-10(2)7-8/h8H,3-7H2,1-2H3/p+1/t8-/m0/s1
5166-67-6 Relevant articles
Reductive Alkylation of Amines with Carboxylic Ortho Esters
Kadyrov, Renat,Moebus, Konrad
supporting information, p. 3352 - 3357 (2020/07/04)
We have demonstrated for the first time ...
REDUCTIVE ALKYLATION OF AMINES WITH ORTHOCARBOXYLIC ACID ESTERS
-
Page/Page column 9; 14, (2017/12/27)
The present invention relates to a proce...
COGNITION ENHANCING COMPOUNDS AND COMPOSITIONS, METHODS OF MAKING, AND METHODS OF TREATING
-
Page/Page column 148, (2012/03/27)
The invention relates generally to musca...
COMPOUNDS AND COMPOSITIONS FOR COGNITION-ENHANCEMENT, METHODS OF MAKING, AND METHODS OF TREATING
-
Page/Page column 126, (2011/08/03)
Disclosed are muscarinic agonist compoun...
5166-67-6 Process route
-
-
50-00-0,30525-89-4,61233-19-0
formaldehyd
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-
71962-74-8
Ethyl nipecotate
-
-
5166-67-6
ethyl 1-methylpiperidine-3-carboxylate
| Conditions | Yield |
|---|---|
|
With
hydrogen; acetic acid;
palladium on activated charcoal;
In
ethanol;
at 20 ℃;
|
42.09 g
|
|
formaldehyd; Ethyl nipecotate;
With
hydrogen; acetic acid;
palladium 10% on activated carbon;
In
water;
at 20 ℃;
for 17h;
under 760.051 Torr;
With
potassium carbonate;
In
water; toluene;
pH=9;
|
-
-
122-51-0
orthoformic acid triethyl ester
-
-
71962-74-8
Ethyl nipecotate
-
-
5166-67-6
ethyl 1-methylpiperidine-3-carboxylate
| Conditions | Yield |
|---|---|
|
With
platinum on carbon; hydrogen; toluene-4-sulfonic acid;
at 120 ℃;
for 0.2h;
under 30003 Torr;
Reagent/catalyst;
Inert atmosphere;
Autoclave;
|
90%
|
|
orthoformic acid triethyl ester; Ethyl nipecotate;
With
platinum on carbon; hydrogen; toluene-4-sulfonic acid;
In
ethanol;
at 25 ℃;
for 24h;
under 30003 Torr;
Autoclave;
With
hydrogenchloride;
In
ethanol; water;
|
90%
|
5166-67-6 Upstream products
-
614-18-6
3-pyridinecarboxylic acid ethyl ester
-
108320-80-5
3-ethoxycarbonyl-1-methyl-pyridinium; bromide
-
56338-90-0
3-ethoxycarbonyl-1-methylpyridinium chloride
-
71962-74-8
Ethyl nipecotate
5166-67-6 Downstream products
-
114193-37-2
N-methyl-N-(3-phenyl-5-isoxazolyl)-1-methylnipecotamide
-
470700-27-7
ethyl 1-methyl-3-(phenylsulfanyl)piperidine-3-carboxylate
-
4842-86-8
ethyl piperidine-3-carboxylate hydrochloride
-
626-67-5
N-methylcyclohexylamine
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